๐ ็ธฝ็ฎ้ ๏ฝ ๐ ่ฑๆๅๆ๏ผๆฌ็ฏ๏ผ ๏ฝ ๐ ๅฎๆด็ฟป่ญฏ ๏ฝ โญ ็ฒพ่ฏ็ญ่จ
Hyperhidrosis
Hyperhidrosis
Although the mechanism of action of BTX in the setting of focal hyperhidrosis has not been fully elucidated, it is likely analogous to its action at the neuromuscular junction. Focal hyperhidrosis is caused in part by an overactivity of the postganglionic sympathetic sudomotor C fibers innervating the eccrine sweat glands.9,10 These sudomotor terminals contain Ach as well as other cotransmitters such as vasoactive intestinal peptide (VIP) and calcitonin geneโrelated peptide (CGRP). By blocking Ach transmission, BTX therapy inhibits eccrine overstimulation and therefore alleviates hyperhidrosis.11,12 As with the neuromuscular junction, chemodenervation with subsequent neural sprouting and reinnervation explain the clinical efficacy and impermanence of this treatment, although the timing of these events may follow a more prolonged course.13