๐ ็ธฝ็ฎ้ ๏ฝ ๐ ่ฑๆๅๆ๏ผๆฌ็ฏ๏ผ ๏ฝ ๐ ๅฎๆด็ฟป่ญฏ ๏ฝ โญ ็ฒพ่ฏ็ญ่จ
Pulsed-dye laser
Pulsed-dye laser
Pulsed-dye laser (PDL) acts through a photochemical effect on porphyrins, resulting in phototoxication and a concomitant photothermal effect on sebaceous glands.30 PDL upregulates transforming growth factor beta (TGF-beta), thereby mediating an antiinflammatory response within the body.34
To date, 14 studies have focused on the use of PDL for acne treatment, 5 of which have combined PDL with a topical agent, such as 5-aminolevulinic acid (ALA). Improvement of inflammatory lesions ranged between 30% and 80% in these studies. However, when PDL was used alone, a significant reduction in inflammatory lesions was reported for four out of six studies.30
The effectiveness of combining PDL (585 nm) and diode laser (1,450 nm) has been shown for mild to moderate inflammatory acne with a mean lesion count reduction of 84% after three treatments. This improvement is not only seen in acne, but also in acne scarring. Adverse effects of this approach include mild erythema and pain, which can be
controlled with topical anesthetics. After the first treatment, a reduction of 37% was reported with the diode laser alone, while a 52% reduction was achieved with both lasers combined. Thus, the combined approach results in a more rapid response. The proposed mechanism of action for diode and PDL lasers entails shrinkage of the oil glands and reduction of P. acnes.35 A firm consensus on the efficacy of PDL for acne treatment has not yet been established.30