๐ ็ธฝ็ฎ้ ๏ฝ ๐ ่ฑๆๅๆ๏ผๆฌ็ฏ๏ผ ๏ฝ ๐ ๅฎๆด็ฟป่ญฏ ๏ฝ โญ ็ฒพ่ฏ็ญ่จ
Dermal remodeling
Dermal remodeling
Aside from the effects of muscular paralysis and sweat gland denervation, BTX therapy has also been observed to promote a global anti-aging effect and to have a potentially positive impact on scar tissue remodeling. In vitro studies have shed some light onto these phenomena. When normal human fibroblasts were cultured in the presence of BTX, upregulation of collagen-1 and collagen-3 protein expression measured by enzyme-linked immunosorbent assay (ELISA) was detected in a dose-dependent fashion. Concurrently, downregulation of matrix metalloproteinases (MMP)-1 and -3 was also observed.14,15 These cellular effects likely contribute to alterations in skin mechanical properties such as elasticity and pliability following BTX treatment.16โ18 Fibroblasts derived from hypertrophic scars, however, may respond differently to BTX than normal, nonscar fibroblasts. In this specific cell population, BTX has an inhibitory effect which may account for its utility in facilitating scar remodeling.19,20 It is important to note that the above data are largely preliminary, and conflicting evidence exists. Further research into these pathways is required.