๐ ็ธฝ็ฎ้ ๏ฝ ๐ ่ฑๆๅๆ๏ผๆฌ็ฏ๏ผ ๏ฝ ๐ ๅฎๆด็ฟป่ญฏ ๏ฝ โญ ็ฒพ่ฏ็ญ่จ
Targeted photothermolysis with exogenous chromophores
Targeted photothermolysis with exogenous chromophores
A light-absorbing chromophore is introduced into the sebaceous follicles and exposed to optical pulses, inhibiting overactive sebaceous glands and hyperkeratinizing cells of the infundibulum.1 Since there are no indigenous chromophores that can absorb the optimal wavelength range of 425 to 550 nm, the sebaceous glands are loaded with a specific exogenous chromophore prior to laser treatment. For example, selective photothermolysis of sebaceous glands with topical indocyanine green (ICG) as a chromophore activated with a diode laser resulted in acne improvement.50
Directly heating the area where P. acnes grows can also result in the reduction of bacteria in the follicle. In optical-particleโassisted selective photothermolysis, lightabsorbing particles are used as mediators for selective photothermolysis of sebaceous follicles. These particles penetrate the infundibulum and sebaceous follicles via vibratory massage. In one study, the particles used were gold-covered silica, and upon exposure to an 800-nm diode laser, the glands were thermally injured. Utilizing particles that exhibit plasma resonance subsequently alleviated inflammatory acne. Further study is needed before these approaches are adopted widely.1