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HISTOPATHOLOGY
HISTOPATHOLOGY
Histologic evaluation of epidermal cysts reveals a stratified squamous epithelium with a granular layer surrounding central laminated keratin. Pilar cysts do not have a granular layer histologically, but do contain compact homogeneous eosinophilic keratin.8 Milia appear histologically similar to, but much smaller than, epidermal cysts.5
In contrast, steatocystomas, or true sebaceous cysts, histologically show a stratified squamous epithelium lined by an eosinophilic cuticle, commonly with sebaceous glands contained within the cyst wall.2 Dermoid cysts are also composed of stratified squamous epithelium with a granular layer, but have additional associated dermal structures such as sebaceous glands, muscle, or hair surrounding the epithelial lining.