๐ ็ธฝ็ฎ้ ๏ฝ ๐ ่ฑๆๅๆ๏ผๆฌ็ฏ๏ผ ๏ฝ ๐ ๅฎๆด็ฟป่ญฏ ๏ฝ โญ ็ฒพ่ฏ็ญ่จ
Adipophilin
Adipophilin
Adipophilin, also known as adipose differentiation-related protein or perilipin 2, is a protein required for the formation and maintenance of lipid droplets. Although its expression is nearly ubiquitous, it has been reported to be a sensitive marker for sebaceous carcinoma.24,35 Adipophilin expression is also seen in a variety of other tumors including SCC with clear cell change, eccrineโapocrine carcinomas,35 and malignant melanoma,36 indicating that lipids are necessary for cellular proliferation with a possible correlation between the expression of adipophilin and the proliferative potential of cancer cells.36 Although other cutaneous malignancies may express adipophilin, a globular staining pattern, as typically expressed in cells with sebaceous differentiation, may be more specific for sebaceous carcinoma. SCC, sweat gland (eccrine and apocrine) carcinomas, and malignant melanoma tend to have more granular
staining.35,36
p63
p63 is a member of the p53 gene family and may play an essential role in regulating the development and differentiation of the epidermis. It is a nuclear marker expressed in the epidermis, eccrine ducts, sebaceous glands, and myoepithelial cells of the eccrine and apocrine glands.37 p63 is overexpressed in SCC and is therefore thought to act as an oncogene.37 p63 staining can be useful in differentiating spindle-cell SCC from other spindle-cell neoplasms such as AFX and melanoma.16,22,37